GSK4112

Overview
Catalog #	bs-83126c-5-mg
Product Name	GSK4112
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Selective Rev-Erbα agonist (EC50=250 nM).1,2 It induces circadian clock phase shifts in isolated primary lung fibroblasts as well as in lung slices (10 µM).1 GSK4112 showed an inhibitory effect on the amplitude of circadian oscillations and caused an arrhythmic expression of canonical clock genes.3 In murine RAW264 macrophages it suppressed inflammatory functions via repressing Ccl2 expression.4 It protected RANKL-induced bone loss via inhibition of osteoclast differentiation in vivo.5
Description	CAS Number: 1216744-19-2 Chemical Name: N-[(4-Chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]glycine, 1,1-dimethyl ester Molecular weight: 396.89 Formula: C18H21ClN2O4S Solubility: DMSO (50 mg/mL) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms)