Remodelin

Overview
Catalog #	bs-83087c-5-mg
Product Name	Remodelin
Specifications
Storage Buffer	Off white or yellow solid
Storage Condition	-20°C
Target
Product Information	Potent and selective inhibitor of N-acetyltransferase 10 (NAT10) which is capable of acetylating microtubules and histones.1 Improves nuclear architecture, chromatin organization and fitness of both human lamin A/C-depleted cells and Hutchinson-Gilford progeria syndrome patient cells1, normalizing progeric and aging cells2. Enhances health span in a mouse model of human accelerated aging syndrome.3 Significantly reduces many of the defects associated with accumulation of the lamin A precursor, prelamin A.4 Inhibits NAT10-promoted metastasis which may be mediated by endothelial-to-mesenchymal transition in hepatocellular carcinoma.5
Description	CAS Number: 949912-58-7 Chemical Name: 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile Molecular weight: 282.36 Formula: C15H14N4S Solubility: DMSO (40 mg/ml) Physical Properties: Pale yellow solid Purity: 98% by HPLC NMR (conforms)