SSAA09E1

Overview
Catalog #	bs-83085c-5-mg
Product Name	SSAA09E1
Specifications
Storage Buffer	Pale-yellow solid
Storage Condition	-20°C
Target
Product Information	SSAA09E1 (433212-75-0) is an inhibitor of SARS coronavirus (SARS-CoV) replication by blocking viral entry (EC50=6.7mM). SSAA09E1 was discovered by screening a chemical library for blocking of entry of HIV-1 pseudotyped with SARS-CoV surface glycoprotein S. The compound acts via inhibition of cathepsin L(IC50=5.33 mM), a host protease required for processing of SARS-S during viral entry. Cathepsin B is not inhibited.1 The compound was also shown to inhibit tyrosinase (IC50=0.14 mM).2
Description	CAS Number: 433212-75-0 Chemical Name: [(Z)-1-Thiophene-2-ylethylideneamino]thiourea Molecular weight: 199.29 Formula: C7H9N3S2 Solubility: DMSO (100 mg/ml); ethanol (10 mg/ml with warming Physical Properties: Beige solid Purity: >98% by TLC NMR (Conforms)