| Overview |
| bsm-70301M |
| Tubulin, beta III Antibody |
| WB, IHC, ICC |
| Specific for endogenous levels of the ~55 kDa beta III tubulin protein. This clone is similar to the monoclonal antibody Tuj1. |
| Mouse, Rat |
| Human, Dog, Bovine, Sheep, Horse, Cat, Rabbit, Guinea Pig, Goat, Hamster, Non-Human Primate, Vole |
| Specifications |
| Unconjugated |
| Mouse |
| Synthetic peptide corresponding to amino acid residues specific to rat beta III tubulin, conjugated to keyhole limpet hemocyanin (KLH). |
| Monoclonal |
| AA10 |
| IgG |
| Lot Dependent |
| Purified by Protein G. |
| 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. |
| Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. |
| Target |
| 246118 |
| Q4QRB4 |
| beta 3 tubulin antibody, beta-4 antibody, beta III Tubulin, CDCBM antibody, CDCBM1 antibody, CFEOM3 antibody, CFEOM3A antibody, FEOM3 antibody, M(beta)3 antibody, M(beta)6 antibody, MC1R antibody, Neuron specific beta III Tubulin antibody, Neuron-specific class III beta-tubulin antibody, QccE-11995 antibody, QccE-15186 antibody, TBB3_HUMAN antibody, Tubb 3 antibody, TUBB3 antibody, TUBB4 antibody, Tubulin beta 3 antibody, Tubulin beta 3 chain antibody, Tubulin beta 4 antibody, Tubulin beta III antibody, Tubulin beta-3 chain antibody, Tubulin beta-4 chain antibody, Tubulin beta-III antibody |
| Tubulin is the major constituent of microtubules, existing as a heterodimer of the α and β subunits. The beta III isoform of tubulin is found almost exclusively in neuronal processes of adult tissues and is therefore an excellent marker for neurons. Neuron specific, posttranslational modifications within the C-terminal domain of beta III tubulin have been shown to be developmentally regulated suggesting that they may serve to modulate the interaction of tubulin with microtubule associated proteins (Lee et al., 1990). Additionally, beta III tubulin has been found to be highly expressed in cancer cells such as small cell lung cancer, large cell neuroendocrine carcinoma and adenocarcinomas and is correlated with an increasing histological degree of malignancy (Katsetos et al., 2003) |
| Application Dilution |
| WB |
1:300-5000 |
| IHC |
|
| ICC |
1:100-500 |
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