Syntaxin Antibody

Applications

Reactivity

Human
Rat
Pig
Hamster

Overview
Catalog #	bsm-70277M
Product Name	Syntaxin Antibody
Applications	WB, IHC
Specificity	Specific for endogenous levels of the ~36 kDa syntaxin protein. The antibody has also been used for immunohistochemistry on formalin fixed, vibratome sections. *Does not work on paraffin sections.
Reactivity	Human, Rat, Pig, Hamster
Specifications
Conjugation	Unconjugated
Host	Mouse
Source	Synaptic immunoprecipitate (crude) from human brain.
Clonality	Monoclonal
Clone #	SP8
Isotype	IgG1
Concentration	Lot Dependent
Purification	Purified by Protein G.
Storage Buffer	10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Storage Condition	Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Target
Gene ID	6804
Swiss Prot	Q16623
Synonyms	HPC 1 antibody, Neuron specific antigen HPC1 antibody, Neuron-specific antigen HPC-1 antibody, OTTHUMP00000174615 antibody, OTTHUMP00000174616 antibody, OTTHUMP00000174617 antibody, OTTHUMP00000174618 antibody, P35-1 antibody, STX1 antibody, STX1A antibody, STX1A_HUMAN antibody, SYN1A antibody, Syntaxin 1A (brain) antibody, Syntaxin 1A brain antibody, Syntaxin-1A antibody
Background	Syntaxins are a family of proteins involved in the docking of synaptic vesicles with the plasma membrane. Syntaxin, along with synaptobrevin and SNAP-25, forms the SNARE complex which mediates synaptic vesicle fusion and exocytosis. Binding of Munc18-1 to the N-terminus of syntaxin 1 has been demonstrated to be essential for exocytic membrane fusion (Khvotchev et al., 2007). Decreased levels of phosphorylated syntaxin 1 in the prefrontal cortex have recently been correlated with schizophrenia (Castillo et al., 2010).
Application Dilution
WB	1:300-5000
IHC