| Overview |
| bsm-62570r-100ul |
| HIF Prolyl Hydroxylases Monoclonal Antibody |
| WB, FCM, IHC-P, IHC-F, IP, IF |
| Human |
| Specifications |
| Unconjugated |
| Rabbit |
| KLH conjugated synthetic peptide derived from human HIF PH4 |
| Monoclonal |
| Recombinant |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Target |
| 54681 |
| Q9NXG6 |
| Cytoplasm |
| EGLN4 ; HIFPH4; Hypoxia inducible factor prolyl 4 hydroxylase; P4H with transmembrane domain; P4htm; PH4; PHD4; Proline 4 hydroxylase; Prolyl hydroxlase domain containing 4. |
| Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. |
| Application Dilution |
| WB |
:1:1000-1:2000 |
| FCM |
FCM:1:20-1:100 |
| IHC-P |
IHC-P:1:100-1:200 |
| IHC-F |
IHC-F:1:100-1:200 |
| IP |
IP:1:20-1:50 |
| IF |
IF:1:100-1:200 |
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