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DNMT3A Polyclonal Antibody

Applications

  • WB
  • ELISA
  • IP
  • ChIP-seq

Reactivity

  • Human
Overview
Catalog # bs-53128R
Product Name DNMT3A Polyclonal Antibody
Applications WB, ELISA, IP, ChIP-seq
Reactivity Human
Specifications
Conjugation Unconjugated
Host Rabbit
Source Polyclonal antibody raised in rabbit against human DNMT3A, (DNA methyltransferase 3A), using a KLH-conjugated synthetic peptide corresponding to amino acids 44-58
Clonality Polyclonal
Isotype Not Determined
Concentration 0.75ug/ul
Purification Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
Storage Buffer PBS with 0.05% sodium azide and 0.05% Proclin300.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 1788
Swiss Prot Q9Y6K1
Synonyms DNMT3A2, TBRS
Background Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Application Dilution
WB 1:300-5000
ELISA 1:500-1000
IP 1-2ug
ChIP-seq