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L3MBTL1 Polyclonal Antibody

Applications

  • WB
  • IP
  • IF

Reactivity

  • Human
Overview
Catalog # bs-53097R
Product Name L3MBTL1 Polyclonal Antibody
Applications WB, IP, IF
Reactivity Human
Specifications
Conjugation Unconjugated
Host Rabbit
Source Polyclonal antibody raised in rabbit against human L3MBTL1 (lethal 3 malignant brain tumor-like protein), using the N-terminal part of the protein
Clonality Polyclonal
Isotype Not Determined
Concentration 2ug/ul
Purification Whole antiserum from rabbit containing 0.05% azide
Storage Buffer PBS with 0.05% sodium azide and 0.05% Proclin300.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 26013
Swiss Prot Q9Y468
Synonyms Lethal(3)malignant brain tumor-like protein 1, L3MBTL1, KIAA0681, L3MBT, L3MBTL
Background Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
Application Dilution
WB 1:300-5000
IP 1-2ug
IF