Olodanrigan
| Overview | |
| Catalog # | bs-83069c-5-mg |
| Product Name | Olodanrigan |
| Specifications | |
| Storage Buffer | Orange solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Potent (IC50 = 39.5 nM) and selective (>10,000-fold selectivity AT2R/AT1R) antagonist of the angiotensin II type 2 receptor.1 It produced dose-dependent relief of hindpaw sensitivity in a rat model of neuropathic pain1 and showed efficacy in a human trial against postherpetic neuralgia2. Olodanrigan prevented paclitaxel-associated acute pain syndrome in mice.3 It blocked visceral hypersensitivity and colonic hyperpermeability in a rat model of irritable bowel syndrome.4 It was also able to inhibit proliferation of AT2R-expressing glioblastoma spheroids and blocked their invasiveness and angiogenic capability.5 |
| Description | CAS Number: 1316755-16-4 Chemical Name: (S)-Benzyloxy-2-diphenylacetyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid Molecular weight: 507.59 Formula: C32H29NO5 Solubility: DMSO (>35 mg/ml) Physical Properties: Off-white solid Purity: >98% by HPLC (NMR Conforms) |
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