BAY 87-2243
| Overview | |
| Catalog # | bs-83058c-5-mg |
| Product Name | BAY 87-2243 |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | RT |
| Target | |
| Product Information | BAY 87-2243 potently inhibits HIF-1 reporter gene activity (IC50 = 0.7 nM) and CA9 protein expression (IC50 = 2.0 nM).1 It inhibited HIF-1 and HIF-2 protein accumulation in hypoxic H460 cells and reduced tumor weight in nude mice inoculated with H460 cells. BAY 87-2243 potently inhibits mitochondrial complex I activity (IC50 = 10 nM in mitochondria isolated from PC3 cells) leading to its HIF-1 effects. It has no effect on mitochondrial complex III. BAY 87-2243 reduced melanoma tumor growth via its targeting of mitochondrial complex I.2,3 |
| Description | CAS Number: 1227158-85-1 Chemical Name: 5-[1-[[2-(4-Cyclopropylpiperazin-1-yl)pyridin-4-yl]methyl]-5-methylpyrazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole Molecular weight: 525.54 Formula: C26H26F3N7O2 Solubility: DMSO (25 mg/ml) Ethanol (10 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms) |
Powered by Bioz