Dp44mT
| Overview | |
| Catalog # | bs-83068c-5-mg |
| Product Name | Dp44mT |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Dp44mT is a metal chelator with potent antitumor activity.1,2 It displayed an average IC50 of 30 nM over 28 cancer cell lines (IC50 range was 5 nM to 400 nM).2 Dp44mT retained its antiproliferative activity in both etoposide-resistant MCF-7/VP clones (MCF-7 breast cancer cells) and vinblastine-resistant KB-VB1 clones (KB3-1 epidermoid carcinoma cells) with an IC50 = 12 nM for both lines.2 The potency of Dp44mT has been attributed to the high redox activity of the Dp44mT-Fe complex leading to cytotoxic ROS generation. The antitumor activity of Dp44mT may also be mediated by a redox active copper complex that causes cellular glutathione depletion and lysosomal damage.3,4 It also inhibited T-cell activation and prevented CD25 up-regulation via a copper-dependent mechanism.5 |
| Description | CAS Number: 152095-12-0 Chemical Name: 3-(Dipyridin-2-ylmethylideneamino)-1,1-dimethylthiourea Molecular weight: 285.37 Formula: C14H15N5S Solubility: DMSO (>25 mg/ml) Physical Properties: Orange solid Purity: 98% by TLC NMR (Conforms) |
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