Alectinib

Overview
Catalog #	bs-83023c-5-mg
Product Name	Alectinib
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Alectinib is a potent (IC50 = 1.9 nM) and highly selective ALK inhibitor.1 It blocked phosphorylation of both native ALK and the L1196M, C1156Y, and F1174L mutants. Alectinib has also been shown to inhibit RET kinase (IC50 = 4.8 nM), the RET gatekeeper mutations V804L and V804M, and inhibited the growth of RET fusion positive cells.2 Alectinib is clinically useful in the treatment of ALK-positive Non-Small Cell Lung Cancer. It effectively suppressed cell proliferation and induced apoptosis in a mouse neuroblastoma xenograft.3
Description	CAS Number: 1256580-46-7 Chemical Name: 9-Ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Molecular weight: 482.62 Formula: C30H34N4O2 Solubility: DMSO (5 mg/ml) Physical Properties: White solid Purity: 99% by HPLC NMr (Conforms)