CB-103

Overview
Catalog #	bs-83004c-20-mg
Product Name	CB-103
Specifications
Storage Buffer	Pale yellow solid
Storage Condition	RT
Target
Product Information	Orally active inhibitor of the Notch signaling activation complex (IC50’s from 0.9 to 3.9 µM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines. CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with γ-secretase Notch inhibitors.
Description	CAS Number: 218457-67-1 Chemical Name: 5-Amino-2-(4-tert-butylphenoxy)pyridine Molecular weight: 242.32 Formula: C15H18N2O Solubility: DMSO (>30 mg/ml) Physical Properties: Off-white to pale orange solid Purity: 98% by HPLC, NMR (Conforms)