R428

Overview
Catalog #	bs-82982c-5-mg
Product Name	R428
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	R428 (1037624-75-1) is a potent and selective inhibitor of AXL kinase (IC50 = 1.4nM).1 R428 has been shown to overcome chemotherapy resistance to various agents in multiple cancer models.2-5 AXL has been shown to suppress myeloid cell activation and function – combined AXL inhibition with R428 and PD-1 blockade showed potent synergistic antitumor effects.6,7
Description	CAS Number: 1037624-75-1 Chemical Name: 1-(3,4-Diazatricyclo[9.4.0.02,7]pentadeca-1(15),2,4,6,11,13-hexaen-5-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine Molecular weight: 506.64 Formula: C30H34N8 Solubility: DMSO (>25 mg/ml) Physical Properties: Yellow solid Purity: 98% by HPLC NMR (Conforms)