AZ20
Overview | |
Catalog # | bs-82981c-5-mg |
Product Name | AZ20 |
Specifications | |
Storage Buffer | White solid |
Storage Condition | -20°C |
Target | |
Product Information | AZ20 is a potent and highly selective inhibitor of Ataxia telangiectasia mutated and RAD3-related (ATR) kinase (IC50 = 5 nM in vitro; IC50 = 50 nM in HT29 colorectal adenocarcinoma cells).1 Combination therapy with AZ20 and gemcitabine resulted in synergistic inhibition of tumor cell growth and cell death initiation in pancreatic cancer cell lines.2 |
Description | CAS Number: 1233339-22-4 Chemical Name: 4-{4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl}-1H-indole Molecular weight: 412.51 Formula: C21H24N4O3S Solubility: DMSO (20 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC NMR (Conforms) |