Lomitapide

Overview
Catalog #	bs-82975c-5-mg
Product Name	Lomitapide
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Lomitapide is a potent (IC50 = 8 nM) inhibitor of microsomal triglyceride transfer protein (MTP or MTTP) and is clinically useful in treating familial hypercholesterolemia.1,2 It has displayed anticancer activity acting through various pathways including autophagy-dependent cancer cell death via direct inhibition of the kinase activity of mTORC13, activation of AMPK/Beclin1-mediated autophagy4, Notch inhibition via targeting TACE and γ-secretase5, blocking ZDHHC5-dependent palmitoylation on SSTR56, PFKFB3 inhibition7, and PARP14/DRP1-mediated mitophagy8.
Description	CAS Number: 182431-12-5 Chemical Name: N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide Molecular weight: 693.73 Formula: C39H37F6N3O2 Solubility: DMSO (50 mg/ml) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms)