PB28 dihydrochloride

Overview
Catalog #	bs-82976c-5-mg
Product Name	PB28 dihydrochloride
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	PB28 is a very potent high affinity (Ki = 5.3 nM1, 0.34 nM2) sigma 2 agonist. Selective for sigma 2 over sigma1 (approx 30-40x).1,2 PB28 inhibited cell growth in MCF7 and MCF7 ADR breast cancer cells and displayed strong synergism with doxorubicin.3 PB28 potently inhibited Kv2.1 currents in a sigma-independent manner.4 PB28 was recently found to have potent (IC50 = 280 nM) anti-SARS-CoV2 activity.5
Description	CAS Number: 172907-03-8 Chemical Name: 1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride Molecular weight: 443.50 Formula: C24H38N2O·2HCl Solubility: DMSO (>25 mg/ml) Water (5 mg/ml) Physical Properties: White or off-white solid Purity: 99% by HPLC NMR (Conforms)