Enasidenib

Overview
Catalog #	bs-82974c-5-mg
Product Name	Enasidenib
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Enasidenib is a potent (IC50’s = 100 nM IDH2R140Q homodimer, 30 nM IDH2R140Q/WT heterodimer and 10 nM IDH2R172K/WT heterodimer) and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2).1 It suppressed the production of the oncometabolite (R)-2-Hydroxyglutarate (a competitive inhibitor of αKG-dependent dioxygenases which leads to epigenetic dysregulation) and induced cellular differentiation in primary human IDH2 mutation-positive acute myeloid leukemia cells.1,2 Recently approved for clinical use by the FDA.
Description	CAS Number: 1446502-11-9 Chemical Name: 2-Methyl-1-[[4-[6(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-2-propanol Molecular weight: 473.38 Formula: C19H17F6N7O Solubility: DMSO (25 mg/ml) Physical Properties: White solid Purity: 98%, NMR (Conforms)