ML365

Overview
Catalog #	bs-82973c-5-mg
Product Name	ML365
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	ML365 is a potent (IC50 = 16 nM) and selective (62-fold selective over TASK-3) blocker of the two-pore domain potassium channel K2P3.1 (TASK-1) .1 It also less potently (IC50 = 4.07 µM) blocks the K2P6.1 (TWIK-2) channel resulting in blocking the ATP-induced NLRP3 inflammasome.2 ML365 improved the efficacy of Levetiracetam in chronically epileptic rats.3 It suppressed the release of TNF-α, IL-6, and IL-1ß in an LPS-induced inflammatory model via regulation of NF-kB signaling.4
Description	CAS Number: 947914-18-3 Chemical Name: 2-Methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide Molecular weight: 360.41 Formula: C22H20N2O3 Solubility: DMSO (>25 mg/ml) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms)