Wnt-C59

Overview
Catalog #	bs-82942c-5-mg
Product Name	Wnt-C59
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	Wnt-C59 is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase. Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms. It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice.1 Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice. Wnt-C59 was able to efficiently differentiate pluripotent stem cells into cortical neurons (CTIP2+/COUP-TF1). Wnt-C59 was also able to dramatically attenuate kidney fibrosis via inhibition of collagen mRNA expression and expression of inflammatory cytokines.
Description	CAS Number: 1243243-89-1 Chemical Name: 4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide Molecular weight: 379.46 Formula: C25H21N3O Solubility: DMSO (7 mg/ml) Ethanol (6 mg/ml). Physical Properties: Tan Solid Purity: >98% by HPLC NMR (Conforms)