SHP099

Overview
Catalog #	bs-82941c-5-mg
Product Name	SHP099
Specifications
Storage Buffer	Orange solid
Storage Condition	-20°C
Target
Product Information	SHP099 is a potent (IC50 = 71 nM) and selective allosteric inhibitor of SHP2. SHP2 is a non-receptor tyrosine phosphatase that regulates cell survival and proliferation through activating the RAS-ERK pathway. It also mediates programmed cell death 1 (PD-1) and T-lymphocyte attenuator (BTLA) immune checkpoint pathways. Treatment with SHP099, in combination with ceritinib, halts growth of ALK-inhibitor resistant non-small-cell lung cancer cells.3 Thus, reduction of SHP2 activity is a potential important cancer therapy target. It showed no activity against a panel of 21 other human phosphatases and 66 kinases.
Description	CAS Number: 1801747-42-1 Chemical Name: 6-(4-Amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine Molecular weight: 352.27 Formula: C16H19Cl2N5 Solubility: DMSO (10 mg/ml) Ethanol (5 mg/ml) Physical Properties: Yellow solid Purity: 98% by HPLC, NMR (Conforms)