D,L-Buthionine Sulfoximine
| Overview | |
| Catalog # | bs-82929c-100-mg |
| Product Name | D,L-Buthionine Sulfoximine |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | D,L-Buthionine sulfoximine is an irreversible inhibitor of γ-glutamylcysteine ligase (GCL). GCL is the first enzyme of the cellular glutathione biosynthetic pathway. Dysregulation of glutathione homeostasis is involved in many diseases including cancer, diabetes, neurodegenerative disorders and HIV/AIDS.1 Most disease states involve decreased glutathione synthesis, however, in cancer, it is increased supporting cellular proliferation and protecting cancer cells. Pharmacological inhibition of GCL has been examined as a potential cancer treatment.2-4 |
| Description | CAS Number: 5072-26-4 Chemical Name: 2(S)-Amino-4-(S-butylsulfonimidoyl)butanoic acid Molecular weight: 222.31 Formula: C8H18N2O3S Solubility: Water (5 mg/ml) Physical Properties: White solid Purity: >98%, NMR (Conforms) |
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