Fumarate hydratase-IN-1
| Overview | |
| Catalog # | bs-82931c-5-mg |
| Product Name | Fumarate hydratase-IN-1 |
| Specifications | |
| Storage Buffer | Off-white to pale yellow low melting point solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Fumarate hydratase-IN-1 is a pro-drug inhibitor of fumarate hydratase, an important enzyme in the tricarboxylic acid (TCA) cycle. This cell permeable compound is converted to the active carboxylic acid by intracellular esterases (Ki = 4.5 µM for free acid). The ethyl ester displayed cell-growth inhibitory activity against several cancer lines under nutrient (glucose) deprived conditions with an average IC50 = 2.2 µM. |
| Description | CAS Number: 1644060-37-6 Chemical Name: Ethyl rel-(3S,3aR)-3-[2-(Methylamino)-2-oxoethyl]-2-oxo-1-[(4-phenylphenyl)methyl]-3,4,5,6-tetrahydroindole-3a-carboxylate Molecular weight: 446.55 Formula: C27H30N2O4 Solubility: DMSO (>25 mg/ml) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms) |
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