Indoximod

Overview
Catalog #	bs-82928c-50-mg
Product Name	Indoximod
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Indoximod is a modulator of indoleamine 2,3-dioxygenase (IDO) activity.1 IDO can be used by tumors to avoid elimination by the host immune response2,3, thus inhibition of IDO is an interesting cancer therapeutic option. Indoximod is not a direct inhibitor of IDO, but instead targets the IDO gene leading to downstream effects.3 IDO-mediated catabolism of tryptophan inhibits the immunoregulatory kinases mTOR and PKC5. This is relieved by Indoximod acting as a potent tryptophan mimetic restoring mTOR and PKC signaling.4
Description	CAS Number: 110117-83-4 Chemical Name: 1-Methyl-D-tryptophan Molecular weight: 218.25 Formula: C12H14N2O2 Solubility: DMSO (>25 mg/ml) Physical Properties: White solid Purity: >98%, NMR (Conforms)