20(S)-Hydroxycholesterol
Overview | |
Catalog # | bs-82906c-1-mg |
Product Name | 20(S)-Hydroxycholesterol |
Specifications | |
Storage Buffer | White or pale yellow solid |
Storage Condition | -20°C |
Target | |
Product Information | 20-(S)-Hydroxycholesterol is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic effects of 20-(S)-hydroxycholesterol have been shown to be mediated by activation of hedgehog signaling and expression of genes associated with Notch signaling.3 Activation of Hedgehog is mediated via binding of 20(S)-hydroxycholesterol to Smoothened at a site distinct from the cyclopamine binding site.4,5 |
Description | CAS Number: 516-72-3 Chemical Name: 5-Cholesten-3β, 20α-diol Molecular weight: 402.66 Formula: C27H46O2 Solubility: DMSO or Ethanol Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms) |