25-Hydroxycholesterol

Overview
Catalog #	bs-82905c-5-mg
Product Name	25-Hydroxycholesterol
Specifications
Storage Buffer	White or pale yellow solid
Storage Condition	-20°C
Target
Product Information	Metabolite resulting from the action of cholesterol 25-hydroxylase on cholesterol. However, since cholesterol 25-hydroxylase knock-out mice still have significant levels of 25-hydroxycholesterol there must be alternate pathways of generation that have yet to be determined.1 Likewise, the biological role of 25-hydroxycholesterol remains somewhat unclear. 25-Hydroxycholesterol is frequently mentioned as an important regulator of cholesterol metabolism, but apparently normal cholesterol regulation in organisms with both high and low levels of the compound make this association unclear. More recent reports have linked 25-hydroxycholesterol and one of it’s metabolites to immunoregulatory roles2, but more information is needed before it’s clear if that is indeed a primary role for the compound.
Description	CAS Number: 2140-46-7 Chemical Name: 5-Cholesten-3β, 25-diol Molecular weight: 402.66 Formula: C27H46O2 Solubility: DMSO or Ethanol Physical Properties: White or pale yellow solid Purity: 98% by TLC, NMR (Conforms)