7alpha-Hydroxycholesterol

Overview
Catalog #	bs-82904c-1-mg
Product Name	7alpha-Hydroxycholesterol
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Metabolite resulting from the action of cholesterol 7 alpha-hydroxylase on cholesterol. 7α-Hydroxycholesterol is the first intermediate and a rate-limiting step in the major pathway for bile acid synthesis in humans. A pro-inflammatory mediator which upregulates production of CCL2 and MMP9 in macrophages and may promote progression of atherosclerosis.2,3 Possible biomarker for cellular lipid peroxidation.4
Description	CAS Number: 566-26-7 Chemical Name: 5-Cholesten-3β, 7α-diol Molecular weight: 402.66 Formula: C27H46O2 Solubility: DMSO or Ethanol Physical Properties: White or pale yellow solid Purity: 98% by TLC [3:2 ethyl acetate : hexane; Rf = 0.15] NMR (Conforms)