Gilteritinib

Overview
Catalog #	bs-82813c-5-mg
Product Name	Gilteritinib
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Potent inhibitor of FLT3 (IC50 = 5 nM, wild-type FLT3) with more potent activity against all FLT3 mutants.1 It also potently inhibits Axl (IC50 = 41 nM). Clinically useful in the treatment of acute myeloid leukemia. Gilteritinib has also been shown to inhibit glutamine uptake and utilization via downregulation of glutamine transporters.2
Description	CAS Number: 1254053-43-4 Chemical Name: 6-Ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide Molecular weight: 552.72 Formula: C29H44N8O3 Solubility: DMSO (25 mg/ml) Physical Properties: Off-white to pale pink solid Purity: 98% by HPLC NMR (Conforms)