PRIMA-1MET

Overview
Catalog #	bs-82815c-5-mg
Product Name	PRIMA-1MET
Specifications
Storage Buffer	Pale yellow solid
Storage Condition	-20°C
Target
Product Information	PRIMA-1MET reactivates mutant p53, an important tumor suppressor gene, in cancer cells.1 It induces p53-dependent mitochondrial apoptosis via activation of caspase-2.2 PRIMA-1MET showed significant antitumor activity in multiple myeloma via activation of p733 and had previously been shown to target p53 family members p63 and p734. Tumor cell death by PRIMA-1MET has been also shown to be caused by glutathione depletion and induced ROS production in a p53 independent manner.5-7 PRIMA-1MET probably induces tumor cell death by both reactivating mutant p53 and inhibiting cellular thiol-dependent redox systems.8
Description	CAS Number: 5291-32-7 Chemical Name: 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one Molecular weight: 199.25 Formula: C10H17NO3 Solubility: DMSO (20 mg/ml) Physical Properties: White solid Purity: 95%, NMR (Conforms)