RU.521

Overview
Catalog #	bs-82809c-5-mg
Product Name	RU.521
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Inhibitor of cyclic GMP-AMP synthase (cGAS), an important innate immune system sensor of foreign cytoplasmic double-stranded DNA.1,2 IC50 = 0.70 µM in dsDNA-stimulated RAW macrophages1 and ~0.80 µM in wild type human THP-1 cells2. It is selective for cGAS with no targeting of IFNB1 protein, interferon receptors, or downstream signaling components of the JAK/STAT pathway. RU.521 was able to significantly increase cardiac output in a mouse model of sepsis.3 Active in both mouse and human cell lines.
Description	CAS Number: 2262452-06-0 Chemical Name: 3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methylpyrazol-4-yl]-3H-isobenzofuran-1-one Molecular weight: 415.23 Formula: C19H12Cl2N4O3 Solubility: DMSO (>25 mg/ml) Physical Properties: Off-white to pale pink solid Purity: 98% by TLC NMR (Conforms)