Alisertib

Overview
Catalog #	bs-82804c-5-mg
Product Name	Alisertib
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Alisertib (MLN8237) is a highly selective and potent (IC50 = 1 nM) cell permeable inhibitor of Aurora A with off-target binding at GABAA (IC50 = 490 nM).1 It disrupts the Aurora A-Myc complex leading to Myc degradation2 in Myc amplified neuroblastomas3 and p53-mutant human hepatocellular carcinoma cell4. Alisertib has been found to induce apoptosis and autophagy in breast cancer5 and melanoma6 cells via suppression of activation of the p38 MAPK pathway.
Description	CAS Number: 1028486-01-2 Chemical Name: 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid Molecular weight: 518.92 Formula: C27H20ClFN4O4 Solubility: DMSO (5 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC, NMR (Conforms)