I-BET762

Overview
Catalog #	bs-82802c-5-mg
Product Name	I-BET762
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	I-BET762 is a potent inhibitor of the BET family of bromodomains with no activity at bromodomains BAZ2B, SP140, ATAD2, CREBBO, and PCAF.1,2 IC50’s for H4Ac peptide displacement: BRD2 = 32.5nM, BRD3 = 42.4nM, BRD4 = 36.1nM.1 It was able to suppress proinflammatory proteins by macrophage, block acute inflammation in mice1, and suppressed the inflammatory function of T cells3. Inhibition of BET bromodomains results in downregulation of Myc transcription, an important oncogene.4
Description	CAS Number: 1260907-17-2 Chemical Name: (4S)- 6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide Molecular weight: 423.90 Formula: C22H22ClN5O2 Solubility: DMSO (>25 mg/ml) Ethanol (>25 mg/ml) Physical Properties: Tan solid Purity: 98% by HPLC, NMR (Conforms)