P22077

Overview
Catalog #	bs-82805c-10-mg
Product Name	P22077
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	P22077 is a selective (tested against 23 other DUBs) inhibitor of USP7 (IC50 = 8 µM) and the closely related USP47.1,2 It destabilizes claspin, a scaffolding protein involved in regulating Chk1 kinase, a DNA damage response enzyme.2 P22077 inhibits neuroblastoma growth via induction of p53-mediated apoptosis.3 N-Myc was destabilized by P22077 inhibition of USP7 in human neuroblastoma cells.4 It was able to stabilize p53 levels in conjunction with an Mdm2 inhibitor (Nutlin-3, Cat# 10-1350) in HCT116 colorectal carcinoma cells.5
Description	CAS Number: 1247819-59-5 Chemical Name: 1-(5-((2,4-Difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone Molecular weight: 315.32 Formula: C12H7F2NO3S2 Solubility: DMSO (25 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC, NMR (Conforms)