AZD5904

Overview
Catalog #	bs-82781c-5-mg
Product Name	AZD5904
Specifications
Storage Buffer	Pale yellow solid
Storage Condition	-20°C
Target
Product Information	A mechanism-based inactivator of myeloperoxidase (IC50 = 200 nM), reacting with hydrogen peroxide in neutrophils to inactivate the enzyme.1 This prevents production of hypochlorous acid and concomitant oxidative stress. Importantly, neutrophil bactericidal activity was slowed but not stopped. AZD5904 did not inactivate thyroid peroxidase or lactoperoxidase. AZD5904 prevented the onset and reversed established high-fat diet induced microvascular insulin resistance.2 It also alleviated the relaxation defect in hypertrophic induced pluripotent cardiomyocytes via restoration of MYBPC3 phosphorylation, suggesting potential therapeutic value in treating hypertrophic cardiomyopathy.3
Description	CAS Number: 618913-30-7 Chemical Name: 3-[[(2R)-Oxolan-2-yl]methyl]-2-sulfanylidene-7H-purin-6-one; 3-[[(2R)-Tetrahydrofuran-2-yl]methyl]-2-thioxo-7H-purin-6-one Molecular weight: 252.29 Formula: C10H12N4O2S Solubility: DMSO (>25 mg/ml) Physical Properties: Yellow solid Purity: >98% TLC, NMR (Conforms)