4μ8C

Overview
Catalog #	bs-82328c-5-mg
Product Name	4μ8C
Specifications
Storage Buffer	Pale-yellow solid
Storage Condition	-20°C
Target
Product Information	Selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of IRE1α and inactivating both XBP1 splicing and IRE1α-mediated mRNA degradation but not IRE1 kinase activity1. Inhibits IRE1α in response to hypoxia or other ER stress-inducing agents but has no effect on proliferation or clonogenic survival of hypoxic cells2. Blocks production of IL-4, IL-5 and IL-13 production in T cells3. Prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in pancreatic β-cells4.
Description	CAS Number: 14003-96-4 Chemical Name: 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde Molecular weight: 204.18 Formula: C11H8O4 Solubility: DMSO (20 mg/ml) Physical Properties: Yellow solid Purity: 97% by TLC NMR (Conforms)