BTB-1

Overview
Catalog #	bs-80329C
Product Name	BTB-1
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:297.7 Formula:C12H8ClNO4S Purity:>98% Solubility:Soluble in DMSO (up to 30 mg/ml) Chemical Name:4-Chloro-2-nitro-1-(phenylsulfonyl)-benzene
Description	A selective, ATP-competitive and reversible inhibitor of mitotic kinesin Kif18A, IC50=1.7 M1,2. Binds to an allosteric site near Kif18A loop 5 preventing a range of conformational changes thereby blocking motor function3. Inhibits the differentiation of mouse bone marrow cells to dendritic cells4. Suppresses the replication of influenza A virus, inhibiting activation of AKT, p38 MAPK, SAPK and RanBP3 leading to the prevention of nuclear export of viral ribonucleoprotein complexes. Greatly improves the viability of IAV-infected mice5.