ISRIB

Overview
Catalog #	bs-80327C
Product Name	ISRIB
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:451.34 Formula:C22H24Cl2N2O4 Purity:>98% Solubility:DMSO (up to 5 mg/ml with warming) Chemical Name:N.N’-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide
Description	Integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM.1 Enhances spatial and fear-associated learning in mice and enhances cognitive function.1,2 Mechanism of action involves activation of eiF2β.3 Suppresses ER stress-induced inflammatory gene expression.4 Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production.5 Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.6