GAC Inhibitor 968
| Overview | |
| Catalog # | bs-80326C |
| Product Name | GAC Inhibitor 968 |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | RT |
| Target | |
| Product Information | Molecular Weight:475.4 Formula:C27H27BrN2O Purity:>98% Solubility:Soluble in DMSO (up to (11 mg/ml); or ethanol (up to 1 mg/ml, warm) Chemical Name:5-(3-bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]-phenanthridin-4(1H)-one |
| Description | Allosteric inhibitor of glutaminase C (GAC)1. Inhibition of GAC blocks oncogenic transformation induced by Rho GTPases in fibroblasts and B lymphoma cells with no effect on normal cells2. Inhibits liver-type glutaminase GLS2 and suppresses breast tumor growth in vivo3,4. Reverses acquired erlotinib resistance in non-small cell lung cancer5. |
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