KU-55933

Overview
Catalog #	bs-80313C
Product Name	KU-55933
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:395.50 Formula:C21H17NO3S2 Purity:>98% Solubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml) Chemical Name:2-(4-Morpholinyl)-6-(1-thiamthrenyl)-4H-pyran-4-one
Description	Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively.1 Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro.2 Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to inhibitors of mitochondrial respiration and translation.3 Sensitizes radio-resistant cancer cells.4 Provides neuroprotection against H2O2-induced cell damage.5