STF-083010
| Overview | |
| Catalog # | bs-80306C |
| Product Name | STF-083010 |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | RT |
| Target | |
| Product Information | Molecular Weight:317.39 Formula:C15H11NO3S2 Purity:>98% Solubility:Soluble in DMSO (up to 30 mg/ml) Chemical Name:N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide |
| Description | A novel small molecule inhibitor of IRE1. It inhibits IRE1 endonuclease activity but not its kinase activity after endoplasmic reticulum stress1-3. It displays significant antimyeloma activity in model human MM xenografts1. Induces apoptosis in pancreatic cancer cells and displays growth inhibition in a clonogenic growth assay in soft agar as well as in a xenograft in vivo model of pancreatic cancer4. Active in vivo. |
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