Rapamycin

Overview
Catalog #	bs-75027c-100ug
Product Name	Rapamycin
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 53123-88-9 Molecular formula: C51H79NO13 Molecular weight: 914.2 Purity: >98% Appearance: White to off-white solid. Solubility: Soluble in DMSO, methanol or chloroform. InChiKey: QFJCIRLUMZQUOT-KIHCOMIKSA-N SMILES: [H][C@@]1(C[C@@H](C)[C@@H]2CC(=O)C(C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@]3([H])CC[C@@H](C)[C@](O)(O3)C(=O)C(=O)N3CCCC[C@@]3([H])C(=O)O2)OC)CC[C@@H](O)[C@@H](C1)OC
Description	Antibiotic. Antibacterial and antifungal properties [1, 2]. Forms a complex with FKBP12 and inhibits the mammalian target of rapamycin (mTOR). Inhibits the response to interleukin-2 (IL-2), and thereby blocks activation of T and B cells [3, 5, 6, 11]. Potent immunosuppressant [4, 10] used as an alternative to calcineurin inhibitors [12]. Restricts the proliferation of smooth-muscle cells by blocking cell cycle progression at the G1/S transition [7, 13]. Anti-proliferative. Antitumor compound [14, 15]. Apoptosis enhancer. Activator of autophagy both in vitro and in vivo [8, 9]. Anti-HIV and anti-aging compound [16, 17]. Neuroprotective [18]. Suppressor for self-renewal and vascular differentiation potential in hemangioma stem cells [19]. mTORC1 inhibitor [20].