Piperlongumine

Overview
Catalog #	bs-75026c-10mg
Product Name	Piperlongumine
Specifications
Storage Buffer	Crystals
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 20069-09-4 Molecular formula: C17H19NO5 Molecular weight: 317.3 Purity: >97% Appearance: White crystals. Solubility: Soluble in DMSO, ethanol, methanol and dimethylformamide. InChiKey: VABYUUZNAVQNPG-BQYQJAHWSA-N SMILES: COC1=CC(\C=C\C(=O)N2CCC=CC2=O)=CC(OC)=C1OC
Description	Cytotoxic against tumor cell lines [3, 4, 5]. Induces necrosis and apoptosis in cancer cells [5, 9, 12]. Shows anti-platelet aggregation activity possibly by inhibition of cyclooxgenase activity and a decrease in thromboxane A2 formation [4, 6, 10]. Shows significant anxiolytic and antidepressant activities [7]. Promotes adipogenesis of 3T3-L1 cells [8]. Induces in vivo and in vitro mutagenicity in eukaryotic models [11]. Selectively kills cancer cells by targeting the stress response to ROS [12]. Shows in vitro schistosomicidal activity [13]. Selective inhibitor of human immunoproteasome. Targets the beta5i subunit (LMP7) (IC50=15µM) with minimal inhibition of human constitutive proteasome [14].