Cyclopamine

Overview
Catalog #	bs-75029c-1mg
Product Name	Cyclopamine
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Target
Product Information	CAS Number: 4449-51-8 Molecular formula: C27H41NO2 Molecular weight: 411.6 Purity: >98% Appearance: White to off-white solid. Solubility: Soluble in ethanol, methanol, DMF or DMSO. Insoluble in water. InChiKey: QASFUMOKHFSJGL-LAFRSMQTSA-N SMILES: [H][C@@]12C[C@H](C)CN[C@@]1([H])[C@@H](C)[C@@]1(CC[C@]3([H])C(C[C@@]4([H])[C@@]3([H])CC=C3C[C@@H](O)CC[C@]43C)=C1C)O2
Description	Cell permeable steroidal alkaloid. Specific sonic hedgehog (Shh) signaling pathway inhibitor. Directly interacts/inhibits Smo (smoothened) [1-4]. Teratogenic [1] and antitumor compound. Inhibits tumor cell growth and progression. Shows selective activity against Shh-dependent tumors [5-11]. Blocks abnormal cell growth associated with oncogenic mutations of Ptch and Smo in fibroblasts [2]. Arrests cell cycle at G0/G1 [6]. Apoptosis inducer [8].