PF-670462 2HCl

Overview
Catalog #	bs-6553c-2mg-solid
Product Name	PF-670462 2HCl
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 410.32 Formula: C19 H22 Cl2 F N5 CAS Number: 950912-80-8 InChi Key: PSNKGVAXBSAHCH-UHFFFAOYSA-N InChi: InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H Smiles: Cl.Cl.NC1N=C(C=CN=1)C1=C(N=CN1C1CCCCC1)C1C=CC(F)=CC=1 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power Shelf Life: 1.0 years
Description	PF-670462 2HCl is a potent inhibitor of the CK1 isoforms CK1ε and CK1δ (IC50 = 7.7 and 14 nM, respectively). Inhibition of CKIepsilon yields a perturbation of oscillator function that forestalls light as a zeitgeber, and they demonstrate that pharmacological tools such as PF-670462 may yield valuable insight into clock function. Casein kinase Iepsilon (CKIepsilon) is an essential component of the biological clock, phosphorylating PER proteins, and in doing so regulating their turnover and nuclear entry in oscillator cells of the suprachiasmatic nucleus (SCN).