Varenicline

Overview
Catalog #	bs-6554c-10mg-solid
Product Name	Varenicline
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 211.26 Formula: C13 H13 N3 CAS Number: 249296-44-4 InChi Key: JQSHBVHOMNKWFT-DTORHVGOSA-N InChi: InChI=1S/C13H13N3/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1/h1-2,4-5,8-9,14H,3,6-7H2/t8-,9+ Smiles: C1NC[C@H]2C[C@@H]1C1C=C3N=CC=NC3=CC=12 Purity: 98.0 Solubility: DMSO: 57 mg/mL(200.57 mM). Appearance: Solid Power Shelf Life: 1.0 years
Description	Varenicline is a nicotinic receptor partial agonist—it stimulates nicotine receptors more weakly than nicotine itself does. In this respect it is similar to cytisine and different from the nicotinic antagonist, bupropion, and nicotine replacement therapies (NRTs) like nicotine patches and nicotine gum. Varenicline displays full agonism on α7 nicotinic acetylcholine receptors and is a partial agonist on the α4β2, α3β4, and α6β2 subtypes. In addition, it is a weak agonist on the α3β2 containing receptors. Varenicline's partial agonism on the α4β2 receptors rather than nicotine's full agonism produces less effect of dopamine release than nicotine's. This α4β2 competitive binding reduces the ability of nicotine to bind and stimulate the mesolimbic dopamine system—similar to the method of action of buprenorphine in the treatment of opioid addiction.