CASIN --- Cdc42 Inhibitor

Overview
Catalog #	bs-60040c-2-mg-solid
Product Name	CASIN --- Cdc42 Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 306.4 Formula: C20 H22 N2 O CAS Number: 425399-05-9 InChi Key: RXIUMAOXORBRCY-UHFFFAOYSA-N InChi: InChI=1S/C20H22N2O/c23-12-11-21-19-8-4-7-16-17-13-15(14-5-2-1-3-6-14)9-10-18(17)22-20(16)19/h1-3,5-6,9-10,13,19,21-23H,4,7-8,11-12H2 Smiles: OCCNC1CCCC2=C1NC1=CC=C(C=C21)C1C=CC=CC=1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	CASIN is a novel and potent Cdc42 inhibitor with an IC50 ~2 µM. In a recent publication in Cell Stem Cell, the elevated activity of the small RhoGTPase Cdc42 in aged HSCs was shown to be causally linked to HSC aging and correlate with a loss of polarity in aged HSCs. CASIN as a specific inhibitor of Cdc42 was shown to functionally rejuvenate aged HSCs, increase the percentage of polarized cells in an aged HSC population, and restore the level and spatial distribution of histone H4 lysine 16 acetylation to a status similar to that seen in young HSCs. CASIN-treated HSCs were further shown to engraft long term in vivo with enhanced repopulation ability.