Cilliobrevin D --- AAA+ ATPase Motor Cytoplasmic Dynein Inhibitor

Overview
Catalog #	bs-60041c-2-mg-solid
Product Name	Cilliobrevin D --- AAA+ ATPase Motor Cytoplasmic Dynein Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 392.62 Formula: C17 H8 Cl3 N3 O2 CAS Number: 1370554-01-0 InChi Key: JKKSCGHDRHRWOQ-VBKFSLOCSA-N InChi: InChI=1S/C17H8Cl3N3O2/c18-8-1-3-10(13(20)5-8)15(24)12(7-21)16-22-14-6-9(19)2-4-11(14)17(25)23-16/h1-6,22H,(H,23,25)/b16-12- Smiles: N#CC(=C1NC(=O)C2=CC=C(Cl)C=C2N1)C(=O)C1C=CC(Cl)=CC=1Cl Purity: 98.0 Solubility: DMSO up to 25mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	Ciliobrevin D is the first specific small molecule antagonist of cytoplasmic dynein, and can inhibit both cytoplasmic dynein 1 and 2. The conversion of chemical energy into mechanical force by AAA+ ATPases is integral to cellular processes, including DNA replication, protein unfolding, cargo transport and membrane fusion. The AAA+ ATPase motor cytoplasmic dynein regulates ciliary trafficking, mitotic spindle formation and organelle transport. Ciliobrevin D perturbs protein trafficking within the primary cilium, leading to their malformation and Hedgehog signaling blockade. It also prevents spindle pole focusing, kinetochore–microtubule attachment, melanosome aggregation and peroxisomemotility in cultured cells. Ciliobrevin D can block dynein-dependent microtubule gliding and ATPase activity in vitro. Therefore it serves as a useful probe for dynein-dependent processes and studying cellular processes that require this microtubule motor.