XAV939---Wnt Antagonist
| Overview | |
| Catalog # | bs-60010c-2mg-solid |
| Product Name | XAV939---Wnt Antagonist |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 312.31 Formula: C14 H11 F3 N2 O S CAS Number: 284028-89-3 InChi Key: KLGQSVMIPOVQAX-UHFFFAOYSA-N InChi: InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20) Smiles: OC1=NC(=NC2CCSCC=21)C1C=CC(=CC=1)C(F)(F)F Purity: 98.0 Solubility: DMSO up to 50 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | XAV939 is a potent and selective Wnt pathway antagonist. It functions to stabilize Axin by inhibiting the poly-ADP-ribosylating enzymes tankyrase 1 and tankyrase 2 with IC50 of 11 nM and 4 nM, respectively. It has been used to study Wnt-dependent cancers. In addition, XAV939 was shown to stabilize Axin2 level in oligodendrocyte precursor cells in the spinal cord and accelerated their differentiation and myelination after hypoxic and demyelinating injury. It can also robustly induce cardiomyocyte differentiation from mouse and human ESCs/iPSCs. |
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