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CD147/Emmprin/Basigin (Extracellular region) Antibody

Applications

  • WB

Reactivity

  • Human
Overview
Catalog # bsm-70410M
Product Name CD147/Emmprin/Basigin (Extracellular region) Antibody
Applications WB
Specificity Clone M052 mouse monoclonal antibody detects a 38-58 kDa* protein on SDS-PAGE immunoblots of human SK-MES1, MDA-MB-231, MeWo, A431, LNCaP, and NCI-H1915 cells, as well as human brain tissues. The antibody works for western blot and ELISA detection of CD147.
Reactivity Human
Specifications
Conjugation Unconjugated
Host Mouse
Source Clone (M052) was generated from a proprietary antigen related to the native human CD147 expressed in NCI-H1915 lung cancer cell line.
Clonality Monoclonal
Clone # M052
Isotype IgG1
Purification Purified by Protein G.
Storage Buffer PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Storage Condition Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Target
Swiss Prot P35613
Synonyms Basigin, 5F7, Collagenase stimulatory factor Extracellular matrix metalloproteinase,EMMPRIN, Leukocyte activation antigen M6, OK blood group antigen, Tumor cell-derived collagenase stimulatory factor, TCSF, CD147, BSG
Background D147 (Basigin/EMMPRIN) is a type I integral membrane receptor protein belonging to the immunoglobulin superfamily. CD147 is a glycosylated protein with four known isoforms with isoform 2 being the most abundantly expressed. In many cancers, CD147 is overexpressed and stimulates the secretion of extracellular matrix metalloproteinases by tumor fibroblasts, which can promote tumor progression. CD147 is co-expressed with the amino acid transporter, CD98h, in metabolically active cells such as lymphocytes, macrophages, and tumor cells. CD147 interaction with caveolin and cyclophilins regulates its functions, and this protein may function outside of tumor cells through cell shedding and microvesicle release.
Application Dilution
WB 1:300-5000