Thyroid Hormone Receptor, ß-Isotype Antibody

Applications

Reactivity

Human

Overview
Catalog #	bsm-70288M
Product Name	Thyroid Hormone Receptor, ß-Isotype Antibody
Applications	WB
Specificity	Specific for endogenous levels of the ~55 kDa TR-β protein.
Reactivity	Human
Specifications
Conjugation	Unconjugated
Host	Mouse
Source	Synthetic peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, β-isotype, conjugated to keyhole limpet hemocyanin (KLH).
Clonality	Monoclonal
Clone #	2386
Isotype	IgG1
Concentration	Lot Dependent
Purification	Purified by Protein G.
Storage Buffer	10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Storage Condition	Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Target
Gene ID	7068
Swiss Prot	P10828
Synonyms	Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2 antibody, C ERBA 2 antibody, C ERBA BETA antibody, c-erbA-2 antibody, c-erbA-beta antibody, ERBA 2 antibody, ERBA BETA antibody, ERBA2 antibody, Erythroblastic leukemia viral (v erb a) oncogene homolog 2 avian antibody, generalized resistance to thyroid hormone antibody, GRTH antibody, MGC126109 antibody, MGC126110 antibody, NR1A2 antibody, Nuclear receptor subfamily 1 group A member 2 antibody, Oncogene ERBA2 antibody, PRTH antibody, THB_HUMAN antibody, THR1 antibody, THRB 1 antibody, THRB 2 antibody, thrB antibody, THRB1 antibody, THRB2 antibody, Thyroid hormone nuclear receptor beta variant 1 antibody, Thyroid hormone receptor beta 1 antibody, Thyroid hormone receptor beta 2 antibody, Thyroid hormone receptor beta antibody, Thyroid hormone receptor beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2 avian) antibody
Background	Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).
Application Dilution
WB	1:300-5000